Friday , September 30 2022

Extract from the bark of jabuticaba fighting pre-diabetes


A team of researchers from the Campinas State University of Biology (IB-Unicamp), supported by the Sao Paulo Research Support Foundation (FAPESP), found that the jabuticaba bark extract, Atlântica, managed to fight pre-diabetes and increased fat accumulation in the liver in elderly mice.

These animals were selected because aging is directly related to decreased metabolic capacity and changes in liver, glucose and lipid metabolism.

During aging there is insufficient control of blood glucose, increased triglyceride deposition in the liver and hormonal imbalance.

In addition, the elderly usually have dyslipidaemia (increased blood fat), hyperinsulinemia (increased blood insulin), diabetes and cardiovascular disease.

To increase aging damage, mice were fed with fat to promote weight gain, increase fat in the liver, stimulate increased blood fat and increase glucose levels.

The diet was five times more fat than a normal diet.

"We have noticed that swallowing jabuticaba bark extract from elderly mice on a high fat diet also caused a decrease in weight gain, increased blood fat and excess blood glucose and improved HDL [colesterol bom] of animals, among other benefits, "said project coordinator Valéria Helena Alves Cagnon Quitete, a professor at IB-Unicamp.

The studies also analyzed the appropriate amount of consumption, as the diet offered to mice had fivefold lipids than a normal diet.

Further research has shown that if animals consumed this diet for 60 days, it would be enough to develop pre-diabetes and liver changes.

Analyzes showed that nutrition prevented weight gain and inflammatory process and favored an improvement in liver morphology.

Now researchers are investigating the use of house jabuticaba extract to delay the progression of prostate cancer in transgenic mice. Preliminary results showed reduced lesions.

"We have seen a significant improvement in the morphology of the prostate mice, as well as a reduction in oxidative stress and inflammation." The reduction in inflammation and the balance of oxidative stress led to tissue and molecular improvement in the animal's prostate, Quitet said.

Extract of the jabuticaba shell

The jabuticaba bark extract was developed in collaboration between IB researchers and the Unicamp School of Food Engineering (FEA).

Through collaboration, the researchers have been able to produce a fruit peel extract that can be administered in a controlled manner and with a high concentration of bioactive compounds (substances naturally occurring in the diet and which have a positive effect on metabolism but are not necessarily nutritional).

Chemical analyzes of the jabuticaba bark extract showed that the compound has a high content of phenolic compounds, such as anthocyanins, also present in red wine, with positive effects on organic metabolism. The passage resulted in the filing of a patent, which is being licensed by a Brazilian company.


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