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Protein with intestinal bacteria to prevent obesity .. How does this happen?



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Protein with intestinal bacteria to prevent obesity .. How does this happen? Breeze News stating that I believe science is spreading protein with intestinal bacteria to prevent obesity. How does it happen? proteins with intestinal bacteria to prevent obesity .. How does it happen? We present today our new news through our news and we start with the news, proteins with intestinal bacteria to prevent obesity. How does this happen?

Naseem News's obesity is associated with high levels of inflammation in the body, but the basic mechanisms are still unclear.

However, a group of researchers recently discovered how an anti-inflammatory protein affects body weight gain, as there is a complex relationship between inflammation, intestinal bacteria and obesity.

A recent study at Cell Host & Microbe says the anti-inflammatory protein NLRP12 protects against obesity and insulin resistance in mice.

The study was conducted by researchers from the University of North Carolina at Chapel Hill, as well as from collaborators from other scientific research institutes around the world.

The researchers also reported that the NLRP12 gene, which encodes the anti-inflammatory protein of the same name, appears to be inactive in people with obesity.

NLRP12 also promotes the development of certain strains of intestinal bacteria (beneficial), which have an additional protective effect against obesity and insulin resistance.

"Obesity is affected by inflammation, not only by taking too many foods but not by exercising," said lead author Jenny P Ting. "This reduces the inflammation that stimulates beneficial bacteria that can help maintain healthy weight."

Influence of gene activity on inflammation

Scientists in a recent study wanted to show how the NLRP12 gene affects the risk of obesity.

To do this, they experimented with mice that were genetically engineered to not express this gene.

Ting and the team gave natural rats and mice a fat-rich diet for several months.

Although mice in both groups followed the same diet, fat accumulation was faster and easier in mice as it began to show signs of insulin resistance, all of which show the development of obesity.

Mice that did not contain the NLRP12 gene also exhibited many inflammations in both the intestine and other areas of their body where the fat was deposited.

However, the researchers took an extra step to understand the relationship between inflammation and weight gain by transferring some of the mice to a different facility and by injecting them with antibiotic drugs to prevent the spread of the disease.

"I noticed that mice injected with antibiotics did not gain weight in contrast to the mice that remained in the old plant," explained Agneska Traxal. "This leads us to doubt the involvement of intestinal bacteria in the promotion of obesity."

Bacteria of the bowel can play an important role

Ting and her medical team investigated mice living in a non-bacterial environment and noted that they did not gain weight.

They concluded that this was because animal systems were unaffected by bacterial activity.

In this case, the fact that mice do not have NLRP12 has no effect on weight gain, suggesting that exposure to certain types of bacteria may be the key to any obesity.

The researchers also noted another interesting fact is that mice that participated in healthy rodents where they lived and who expressed the NLRP12 gene were not exposed to weight gain.

This shows that they have been exposed to beneficial bacteria by controlled mice, which protect them from exposure to increased weight.

Such findings indicate the context in which studies have shown that obesity is associated with loss of bacterial diversity in the intestine.

In addition, certain strains of bacteria are suppressed in the case of obesity, allowing the rest of the bacteria to breed without competition.

Risks of bacterial loss

In the recent study, the researchers found that rats that did not have the NLRP12 experiments offered significant loss of bacterial diversity.

In this case, a fat-rich diet is combined with an increase in inflammation due to the lack of presence of high levels of NLRP12 (Erysipelotrichaceae.

The researchers also found that these bacteria exacerbate the damage caused by the high-fat diet.

At the same time, the mice lost a number of beneficial lactobacteria (Lachnospiraceae), which help fight infection and compete with Erysipelotrichaceae to stop their spread.

The researchers found that Lachnospiraceae also appear to have a protective effect against insulin resistance and obesity in mice.

"When we added the Lachnospiracea bacteria, it basically reflected all the metabolic and inflammatory changes we saw in NLRP12 for test mice during a high fat diet," Trax said.

Results can lead to better ways to deal with obesity.

"Lactobacterium (Lachnospiraceae) produces a small chain of fatty acids, a kind of molecule that plays an important role in metabolism," the scientists said.

Both butyrate and propionate also have important anti-inflammatory properties.

When they tried to give butter and probiotics to try mice, the researchers observed that this approach was parallel to the effect of NLRP12 loss.

Emerging treatment options

These results particularly encourage that butyrates and propionates are readily available as supplements.

In addition, scientists have a good reason to believe that the reactions (in mice) will be the same for humans because additional analyzes of fat cells collected by obese people suggest that the higher the body-BMI), the more active it is the NLRP12 gene.

"In rats, we have shown that NLRP12 reduces inflammation in the intestines and adipose tissue, and although it is difficult to demonstrate a direct causal effect on humans, our collaborators have helped us show low levels of NLRP12 expression in people who are considered obese," he says Jenny Ping. .


  • Translation: Zeinab Abbas.
  • Control: Suha Yazji.
  • Editing: Issa Hazeem.
  • Source

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