Wednesday , February 1 2023

modifying a gene may be more effective than the vaccine


Researchers would have found an alternative to influenza vaccine. Their study, possibly revolutionary, was published in the journal science, shows that a gene to be inserted into the genetic cell of the nose cells allows them to secrete an antibody capable of fighting 59 influenza virus strains than the 60 tested.

The vaccine is never 100% effective

As the influenza virus is constantly and accidentally mutated, the vaccine is never 100% effective: every year, viruses change enough to escape the immune response developed against the virus. last year: they can infect people who have already done the flu, and vaccination must be repeated every year.

In particular, even if it is adapted each year according to different parameters (virus circulating in the past year and in different regions of the world, probability analysis …) and if it is targeted at many strains, the influenza vaccine can only partially cover the viruses that will actually appear. Above all, if during the 2017-2017 epidemic there were 2 viruses: the vaccine was effective against the first (virus A (H1N1) pdm09) but not against the 2nd (Yamagata B virus) to develop due to of the duration of the epidemic.

In the end and for all these reasons, influenza vaccine can not be 100% effective and this is partly because it is avoided by many French people.

Other strategies being tested

There is, of course, the Global Vaccine Grail, which is directed against a more stable and more universal component of the virus, but we are still far from it. On the other hand, looking for other ways to fight influenza, scientists have discovered that some people produce natural antibodies that can fight many influenza virus strains.

They then created a gene capable of producing the production of these antibodies and then injected into the mouse nose cells with an innocuous virus vector ("transfection"). The mouse nose cells that received the transplantation of this gene were then able to make this famous antibody. Sixty influenza virus strains were then tested by vaccination in these animals and only one strain of the 60 was not controlled by the antibodies … but 59 were.

Multidomain Antibody

"The MD3606 multi-domain antibody protects mice from influenza A and B infections when administered intravenously," the researchers concluded. "Our results demonstrate that multi-domain antibodies have increased cross-reactivity and viral activity and can be an effective strategy to prevent influenza and other variable pathogens," they add.

It's interesting, but it's in the mouse and this should not prevent you from vaccinating this year with the flu. Not even 100% effective, influenza vaccine protects against most serious infections: Last year, the vast majority

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